Akrit Sodhi Selected Research

Hypoxia (Hypoxemia)

5/2024	Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.
1/2023	HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease.
1/2022	PAI-1 is a vascular cell-specific HIF-2-dependent angiogenic factor that promotes retinal neovascularization in diabetic patients.
1/2017	Endothelial adenosine A2a receptor-mediated glycolysis is essential for pathological retinal angiogenesis.
1/2017	Hypoxia-Inducible Factor-Dependent Expression of Angiopoietin-Like 4 by Conjunctival Epithelial Cells Promotes the Angiogenic Phenotype of Pterygia.
1/2017	Anti-angiogenic Therapy for Retinal Disease.
12/2016	Expression Pattern of HIF-1α and VEGF Supports Circumferential Application of Scatter Laser for Proliferative Sickle Retinopathy.
2/2016	Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma.
1/2014	Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation.
11/2013	VEGF secreted by hypoxic Müller cells induces MMP-2 expression and activity in endothelial cells to promote retinal neovascularization in proliferative diabetic retinopathy.

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Akrit Sodhi Research Topics

Disease

12	Neoplasms (Cancer) 05/2024 - 04/2004
11	Hypoxia (Hypoxemia) 05/2024 - 09/2013
10	Eye Diseases (Eye Disease) 01/2023 - 09/2013
9	Macular Degeneration (Age-Related Maculopathy) 03/2024 - 01/2015
9	Diabetic Retinopathy (Retinopathy, Diabetic) 01/2023 - 11/2013
7	Macular Edema 11/2019 - 10/2013
7	Kaposi Sarcoma (Kaposi's Sarcoma) 10/2015 - 04/2004
6	Blindness (Hysterical Blindness) 08/2023 - 01/2017
6	Retinal Neovascularization 01/2022 - 11/2013
6	Retinal Vein Occlusion 01/2019 - 10/2013
5	Choroidal Neovascularization 03/2024 - 08/2013
5	Edema (Dropsy) 01/2019 - 10/2013
4	Pathologic Neovascularization 11/2022 - 01/2017
4	Uveal melanoma 03/2021 - 01/2014
4	Ischemia 12/2016 - 09/2013
3	Carcinogenesis 05/2024 - 11/2004
3	Squamous Cell Carcinoma of Head and Neck 05/2024 - 11/2005
3	Vascular Diseases (Vascular Disease) 01/2021 - 01/2017
3	Sickle Cell Anemia (Hemoglobin S Disease) 01/2021 - 12/2016
3	Retinal Diseases 01/2017 - 01/2017
2	Fibrosis (Cirrhosis) 03/2024 - 01/2015
2	Inflammation (Inflammations) 01/2023 - 01/2013
2	Infections 10/2015 - 11/2004
1	Oral Leukoplakia 05/2024
1	Necrosis 05/2024
1	Neoplasm Metastasis (Metastasis) 05/2024
1	Cardiovascular Diseases (Cardiovascular Disease) 03/2024
1	Vision Disorders (Hemeralopia) 12/2023
1	Bites and Stings (Sting) 01/2023
1	Cavernous Hemangioma (Cavernous Angioma) 01/2023
1	Vascular System Injuries 10/2022
1	Disease Progression 01/2022
1	Adenocarcinoma 01/2022
1	Pathologic Processes 01/2022
1	Hepatocellular Carcinoma (Hepatoma) 01/2022
1	Hemorrhage 01/2018
1	Retinopathy of Prematurity (Retrolental Fibroplasia) 01/2017

Drug/Important Bio-Agent (IBA)

26	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2024 - 04/2011
17	Retinaldehyde (Retinal)IBA 08/2023 - 08/2013
9	AngiopoietinsIBA 05/2024 - 08/2010
6	CytokinesIBA 05/2024 - 11/2004
6	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2014
5	Transcription Factors (Transcription Factor)IBA 01/2022 - 01/2017
5	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 08/2010 - 04/2004
4	Phosphotransferases (Kinase)IBA 05/2024 - 11/2005
4	Hypoxia-Inducible Factor 1IBA 12/2023 - 02/2016
4	Oxygen (Dioxygen)IBA 01/2020 - 09/2013
4	Ranibizumab (Lucentis)FDA Link 03/2016 - 10/2013
3	Angiogenesis Inducing Agents (Angiogenesis Factor)IBA 01/2022 - 06/2015
2	LigandsIBA 05/2024 - 01/2014
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2024 - 11/2004
2	Purinergic P1 Receptors (Adenosine Receptor)IBA 03/2024 - 01/2017
2	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 10/2022
2	Small Interfering RNA (siRNA)IBA 01/2023 - 01/2014
2	afliberceptIBA 01/2023 - 01/2021
2	Bevacizumab (Avastin)FDA Link 01/2023 - 01/2021
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 11/2022 - 04/2004
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 06/2015
2	EnzymesIBA 01/2017 - 01/2017
2	Dexamethasone (Maxidex)FDA LinkGeneric 08/2016 - 08/2015
2	Digoxin (Digitek)FDA LinkGeneric 01/2014 - 09/2013
1	p38 Mitogen-Activated Protein KinasesIBA 05/2024
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 05/2024
1	AmphiregulinIBA 05/2024
1	Interleukin-12 (IL 12)IBA 05/2024
1	ErbB Receptors (EGF Receptor)IBA 05/2024
1	ChemokinesIBA 05/2024
1	Platelet-Derived Growth FactorIBA 05/2024
1	Interleukin-11 (Interleukin 11)IBA 05/2024
1	Interleukin-1alpha (Interleukin 1 alpha)IBA 05/2024
1	VLDL LipoproteinsIBA 03/2024
1	istradefyllineIBA 03/2024
1	VitaminsIBA 12/2023
1	AntioxidantsIBA 12/2023
1	Dasatinib (BMS 354825)FDA Link 01/2023
1	bleomycetinIBA 01/2023
1	InterferonsIBA 01/2023
1	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2023
1	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 01/2023
1	PaxillinIBA 01/2023
1	Retinal Pigments (Pigments, Visual)IBA 10/2022
1	Plasminogen Activator Inhibitor 1IBA 01/2022
1	Glycoproteins (Glycoprotein)IBA 01/2022
1	FructoseIBA 01/2020
1	NeuropilinsIBA 11/2019
1	Epoxide HydrolasesIBA 12/2017
1	Adenosine A2A Receptor (Adenosine A2A Receptors)IBA 01/2017
1	ImmunosorbentsIBA 01/2017
1	Endocrine-Gland-Derived Vascular Endothelial Growth Factor (Vascular Endothelial Growth Factor, Endocrine Gland Derived)IBA 08/2016
1	ProlactinIBA 08/2016
1	Insulin-Like PeptidesIBA 08/2016
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 08/2016
1	Angiopoietin-2IBA 08/2016
1	Semaphorins (Semaphorin)IBA 01/2016

Therapy/Procedure

16	Therapeutics 03/2024 - 01/2006
7	Lasers (Laser) 03/2024 - 10/2013
3	Drug Therapy (Chemotherapy) 01/2021 - 08/2013
3	Injections 01/2019 - 10/2013
2	Light Coagulation 01/2022 - 07/2015
1	Intraocular Injections 01/2022